Cần Thơ Bridge is a cable-stayed bridge over the Hậu (Bassac) River, the largest distributaries of the Mekong River, in the city of Cần Thơ in southern Vietnam. The bridge is 2.75 kilometers long. It has a 6-lane carriage way measuring 23 meters in width, with 4 lanes for traffic and two pedestrian lanes. It has a clearance of 39 meters, which will allow large ships to pass underneath the bridge. The bridge was inaugurated on April 24, 2010.

The bridge is currently the longest main span cable-stayed bridge in Southeast Asia. The cost of construction is estimated to be 4.842 trillion Vietnamese đồng (approximately 342.6 million U.S. dollars), making it the most expensive bridge in Vietnam.

Cần Thơ City constitutes an independent municipality at the same level as provinces of Vietnam. It was created in the beginning of 2004 by a split of the former Cần Thơ Province into two new administrative units: Cần Thơ City and Hậu Giang Province.

It borders the provinces of An Giang, Hậu Giang, Kiên Giang, Vĩnh Long and Đồng Tháp.

Can Tho is connected to the rest of the country by National Road 1A and Can Tho Airport. The Can Tho Bridge is opened for the traffic on April 2010. The 6-lane Saigon-Can Tho express way is also done in parts from Ho Chi Minh City to Trung Luong of My Tho. The hydrofoil express boat links this city with Saigon.